Association between the DNA Repair Gene Polymorphisms and Lung Cancer in Turkish Population

Introduction: DNA repair enzymes continuously monitor to correct damaged nucleotide residues generated by exposure environmental mutagenic and cytotoxic compounds or carcinogens. Our objective was investigate the association among XRCC1 (Arg399Gln Arg194Trp), XRCC3 (Thr241Met), XPD-ERCC2 (Lys751Gln), APE1 (Asp241Glu), PARP-ADPRT (Val762Ala) gene polymorphisms lung cancer in Turkish population. Materials Methods: patient group consists of 90 patients with control had 100 healthy individuals all those smoking. extracted using whole blood samples. PCR- RFLP technique used on target genes. Results: There no significant difference genotype distributions XPD Lys751Gln, Arg194Trp, Thr241Met, Asp241Glu between controls for each polymorphism (p > 0.05). However, there a Arg399Gln, PARP Val762Ala Discussion: Only codon 399 alleles are associated risk cancer. Other genotypes were not related